ENZYMURIA AS AN INDEX OF RENAL DAMAGE IN CANINE LEISHMANIASIS

Urinary enzyme activities of alanine aminopeptidase, gammaglutamyl tra nspeptidase, alkaline phosphatase, N-acetyl-beta-D-glucosaminidase and beta-glucuronidase were determined in 15 dogs with leishmaniasis and in a group of eight normal dogs. Serum creatinine and blood urea nitro gen concentrations were also measured and renal histology was examined . All the affected dogs had renal lesions. However, no significant dif ferences in blood urea nitrogen and creatinine concentrations were fou nd between the control group and the affected group. The urinary enzym e activities of gamma-glutamyl transpeptidase (P<0.01), N-acetyl-beta- D-glucosaminidase (P<0.01) and beta-glucuronidase (P<0.05) were signif icantly higher in the affected dogs. Urinary enzymes therefore seem to be a more sensitive and reliable test for assessing early renal damag e in canine leishmaniasis than serum creatinine or blood urea nitrogen concentrations.