THE D-2 RECEPTOR - LOVE IT AND LEAVE IT

Occupancy of the D-2 receptor has been a foundation for the mechanism of antipsychotic action for over two decades. The introduction of atyp ical antipsychotics and their multiple receptor profiles coupled with functional brain imaging technology has raised questions about what on ce was considered to be a very tight concept. We address controversial facets to the D, receptor's involvement in the antipsychotic mechanis m and point to future clinical research directions.