INFLUENCES OF THE BED NUCLEUS OF THE STRIA TERMINALIS AND OF THE PARAVENTRICULAR NUCLEUS OF THE HYPOTHALAMUS ON THE EXCITABILITY OF HIPPOCAMPAL-LATERAL SEPTAL SYNAPSES IN MICE
K. Nailboucherie et al., INFLUENCES OF THE BED NUCLEUS OF THE STRIA TERMINALIS AND OF THE PARAVENTRICULAR NUCLEUS OF THE HYPOTHALAMUS ON THE EXCITABILITY OF HIPPOCAMPAL-LATERAL SEPTAL SYNAPSES IN MICE, Neuroscience letters, 246(2), 1998, pp. 112-116
Previous experiments have shown that conditioning in aversive situatio
ns is associated with specific changes in excitability of hippocampal-
septal synaptic transmission and that these changes might be related t
o a modulation of this synaptic transmission by afferents originating
from the bed nucleus of the stria terminalis (BNST) and from the parav
entricular nucleus (PVN) of the hypothalamus. Accordingly, the aim of
the present experiment was to assess changes in excitability of hippoc
ampal-septal synapses by varying the interval between the application
of a conditioning pulse in either the BNST or the PVN, and a test puls
e in fimbria fibers (FF). Electrical stimulation of FF, induces in the
lateral septum (LS) a field potential characterized by two negative w
aves (N2 and N3) the magnitude of which is an index of excitability of
two populations of target cells located in the ventral and dorsal lat
eral septum, respectively. Results showed that prestimulation of both
the BNST and the PVN produced an increase in the amplitude of the N3 w
ave, although the optimal interpulse interval required for producing m
aximal increase was different as a function of the two structures. Onl
y prestimulation of the BNST induced a significant increase in the amp
litude of the N2 wave. These results suggest that the PVN projects mai
nly to the dorsal aspect of the LS, while the BNST projects to both do
rsal and ventral parts of the LS. Together with results from previous
experiments conducted in behaving mice exposed to conditioned aversive
stimuli, it is concluded that these projections might play a role in
the relief of contextual conditioned fear. (C) 1998 Published by Elsev
ier Science Ireland Ltd.