E. Naslund et al., DISTAL SMALL-BOWEL HORMONES - CORRELATION WITH FASTING ANTRODUODENAL MOTILITY AND GASTRIC-EMPTYING, Digestive diseases and sciences, 43(5), 1998, pp. 945-952
The aim of the present study was to study the interdigestive motor com
plex (MMC), distal small intestinal hormones, and gastric emptying in
normal-weight and obese subjects before and after jejunoileal bypass (
JIB). Therefore, fasting antroduodenal motility, gastric emptying, and
RIA for motilin (MOT), neurotensin (NT), peptide YY (PW), and glucago
n-like peptide-1 (GLP-1) was performed in nine obese subjects before (
BMI 42 +/- 4 kg/m(2)) and nine months after (BMI 31 +/- 4) JIB, and in
two groups of nine age-and sex-matched controls (BMI 23 +/- 1 and 21
+/- 1). The rate of gastric emptying was faster in obese subjects and
GLP-1 lower compared to normal-weight controls. After JIB, fewer phase
III of the MMC were observed; fasting levels of PYY were elevated dur
ing the MMC; postprandial levels of NT, PW, and GLP-1 were elevated; a
nd gastric emptying was delayed. Our results suggest that there may be
an association between an impaired GLP-1 response after food intake a
nd obesity, and after JIB, PYY seems to regulate interdigestive motili
ty while GLP-1 may regulate early gastric emptying.