ETHNOPHARMACOLOGY OF MEXICAN ASTERACEAE (COMPOSITAE)

Traditional herbal remedies have increased in popularity in Europe and the United States in recent years but have always been important to p eople living in rural Mexico and to their Mexican American/Chicano des cendants in the United States. Mexican American patients will often be ingesting herbal teas at the same time that they are being treated fo r their ailments with antibiotics or antiinflammatory agents. The plan t family Asteraceae (Compositae) has contributed the largest number of plants to this pharmacopoeia; the reasons for the importance of this family include its large number of species in Mexico and its wide arra y of natural products that are useful in the treatment of the maladies that have afflicted the inhabitants of rural Mexico. These natural pr oducts include sesquiterpene lactones, polyacetylenes, alkaloids, mono terpenes, and various phenolics such as flavonoids. In this review, we emphasize the sesquiterpene lactones, a large group of compounds with antiinflammatory properties and the ability to relax smooth muscles a nd thereby relieve gastrointestinal distress. These compounds also rea dily form adducts with glutathione or free thiols and can thereby affe ct the metabolism, activity, and toxicology of a wide array of pharmac ological agents.