Jl. Beckerman et al., INHIBITION OF PATHOGENICITY OF THE RICE BLAST FUNGUS BY SACCHAROMYCES-CEREVISIAE ALPHA-FACTOR, Science, 276(5315), 1997, pp. 1116-1119
Magnaporthe grisea is a fungal pathogen with two mating types, MAT1-1
and MAT1-2, that forms a specialized cell necessary for pathogenesis,
the appressorium, Saccharomyces cerevisiae alpha-factor pheromone bloc
ked appressorium formation in a mating type-specific manner and protec
ted plants from infection by MAT1-2 strains. Experiments with alpha-fa
ctor analogs suggest that the observed activity is due to a specific i
nteraction of alpha-factor with an M. grisea receptor. Culture filtrat
es of a MAT1-1 strain contained an activity that inhibited appressoriu
m formation of mating type MAT1-2 strains. These findings provide evid
ence that a pheromone response pathway exists in M. grisea that can be
exploited for plant protection.