NEW (PERFLUOROALKYL)ALKYL DIMETHYLAMMONIUM BROMIDE-BASED VESICLES EXHIBITING TRAPPING AND RELEASE PROPERTIES - STUDY OF THEIR TOXICITY IN CONTACT WITH SKIN

In the present work, we show that sonication of ammonium amphiphiles c ontaining one long perfluoroalkyl tail and one long hydrocarbon tail i n aqueous solution (buffer at pH 7.4) produces vesicular systems capab le to entrap and release different rates of calcein. Moreover, we show that these systems can be considered as non-toxic after topical appli cation onto skin rabbit. The vesicular systems are characterized by fr eeze-fracture electron microscopy, their mean diameter measured by pho ton correlation spectroscopy (PCS), their ability to entrap and releas e calcein determined spectrofluorimetrically.