WHY ZINC IN ZINC-FINGERS

Authors
REDDY PR
Citation
Pr. Reddy, WHY ZINC IN ZINC-FINGERS, Indian journal of chemistry. Sect. A: Inorganic, physical, theoretical & analytical, 37(1), 1998, pp. 53-55
Citations number
21
Categorie Soggetti
Chemistry
Journal title
Indian journal of chemistry. Sect. A: Inorganic, physical, theoretical & analytical
ISSN journal
03764710 → ACNP
Volume
37
Issue
1
Year of publication
1998
Pages
53 - 55
Database
ISI
SICI code
0376-4710(1998)37:1<53:>2.0.ZU;2-Q
Abstract
It is found that Zn complex based units are present in a number of nuc leic acid binding and gene regulatory proteins. The Zn is a crucial co mponent of the tertiary structure of ''Zn-finger'' since the two invar iant cysteines and two invariant histidines which constitute each of t he nine tandem repeats of amino acid motif are coordinated to Zn in a tetrahedral configuration (Zn-core). An attempt has been made to reaso n why Zn is present in ''Zn-fingers'' based on the assessment of the s tability aspect of the core with Zn and Co.