THE EFFECTS OF PROSTAGLANDIN E-1 AND TYROSINE KINASE INHIBITORS ON ENERGY STATUS AND PROTEIN SYNTHETIC ABILITY IN HEPATIC ISCHEMIA-REPERFUSION INJURY

The effects of prostaglandin E-1 (PGE(1)) and tyrosine kinase inhibito rs on hepatic energy status and protein synthesis in ischemic livers w ere studied using P-31-magnetic resonance spectroscopy in a rat model. The continuous administration of PGE(1) significantly increased the b eta-adenosine triphosphate/inorganic phosphate (beta-ATP/P-i) ratio an d hepatic protein synthesis rate (HPS) after ischemia-reperfusion inju ry, Microscopic examination showed that the continuous administration of PGE(1) inhibited the development of sinusoidal hemorrhage and edema . Thus, it was concluded that PGE(1) has a beneficial effect on ischem ia-reperfusion injury in the liver. Pretreatment with tyrosine kinase inhibitor also increased the beta-ATP/P-i ratio; however, when tyrosin e kinase inhibitor was injected before ischemia, the HPS became signif icantly reduced. Based on these data, the protective effect of tyrosin e kinase inhibitor is unconvincing.