NOVEL PHOSPHATE ESTER-LINKED RESINS - THE SOLID-PHASE GENERATION OF PHENYL PHOSPHATE-CONTAINING COMPOUNDS FOR SH2 INHIBITION

Authors
METCALF CA VU CB SUNDARAMOORTHI R JACOBSEN VA LABORDE EA GREEN J GREEN Y MACEK KJ MERRY TJ PRADEEPAN SG UESUGI M VARKHEDKAR VM HOLT DA
Citation
Ca. Metcalf et al., NOVEL PHOSPHATE ESTER-LINKED RESINS - THE SOLID-PHASE GENERATION OF PHENYL PHOSPHATE-CONTAINING COMPOUNDS FOR SH2 INHIBITION, Tetrahedron letters, 39(21), 1998, pp. 3435-3438
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
21
Year of publication
1998
Pages
3435 - 3438
Database
ISI
SICI code
0040-4039(1998)39:21<3435:NPER-T>2.0.ZU;2-9
Abstract
An efficient method for the preparation of protected phosphate ester-l inked resins in high yield and purity is presented. Variation in tethe r length/functionality and substitution pattern of the phenol precurso rs, as well as mild deprotection conditions make this system ideal for the combinatorial generation of phenyl phosphate SH2 inhibitor librar ies. (C) 1998 Elsevier Science Ltd. All rights reserved.