A HIGHLY ENANTIOSELECTIVE ASYMMETRIC HYDROGENATION ROUTE TO BETA-(2R,3S)-METHYLTRYPTOPHAN

Authors
HOERRNER RS ASKIN D VOLANTE RP REIDER PJ
Citation
Rs. Hoerrner et al., A HIGHLY ENANTIOSELECTIVE ASYMMETRIC HYDROGENATION ROUTE TO BETA-(2R,3S)-METHYLTRYPTOPHAN, Tetrahedron letters, 39(21), 1998, pp. 3455-3458
Citations number
23
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
21
Year of publication
1998
Pages
3455 - 3458
Database
ISI
SICI code
0040-4039(1998)39:21<3455:AHEAHR>2.0.ZU;2-5
Abstract
Asymmetric hydrogenation of a protected (Z)-dehydro-beta-methyltryptop han derivative 2 with (R,R)-Me-DuPHOS-Rh catalysis was achieved in 97 % ee. Deprotection then afforded (2R,3S)-beta-methyltryptophan 1. (C) 1998 Elsevier Science Ltd. All rights reserved.