SOLID-STATE BETA-CYCLODEXTRIN COMPLEXES CONTAINING INDOMETHACIN, AMMONIA AND WATER - I - FORMATION STUDIES

Five complexes were prepared with beta-cyclodextrin and the insoluble, non-steroidal, anti-inflammatory drug indomethacin. The complexes wer e found to contain drug, water and ammonia in several unique combinati ons. It was theorized the complexes were tri-molecular in nature and t heir formation was controlled by a hydrophobic/hydrophilic balance cre ated within the beta-cyclodextrin ring cavity prior to complex formati on. Each complex was characterized by ultraviolet, infrared, nuclear m agnetic resonance, powder X-ray diffraction, differential scanning cal orimetry, and thermogravimetric techniques. These characterizations re vealed distinct differences among the five complexes. (C) 1998 Elsevie r Science B.V. All rights reserved.