VARIOUS STATISTICAL-METHODS IN USE FOR EVALUATING HUMAN-MALIGNANT GASTRIC SPECIMENS

This paper presents the use of certain statistical methods (comparison of means - independent samples t-test, multiple linear regression ana lysis, multiple logistic regression analysis, analysis of clusters, et c.) included in the SPSS Statistical Package used to classify the pati ents quantitatively evaluated after a subtotal resection of their stom achs. The group consisted of 40 patients subdivided into two groups: p rimary neoplasia of the stomach (20 patients), and corresponding lymph ogenic deposits in the abdominal perigastric lymph nodes (20 patients) . Paraffin-embedded tissue sections (thickness 4-5 mu m) prepared as c onsecutive hematoxylin-eosin-stained slides were morphometrically meas ured by a rotation of a graduated eyepiece-micrometer; thus, we obtain ed the minor and major axes' lengths of the elliptic nuclear profiles and the minor and major caliper diameters of the corresponding cellula r profiles. These four variables were used to determine the dynamic ch anges in quantitative features of human gastric lesions when passing f rom normal histological structures, through hyperplastic processes (ch ronic gastritis), gastric precancer (ulcers and polyps with or without malignancy) till the development of primary carcinomas and their corr esponding lymphogeneous metastases. Besides the increased cytomorphome trical measures, we also noted an opportunity to classify the patients according to these data as well as to add to the knowledge of our con sultation system for clinical aid and use, recently published in the l iterature.