TROVAFLOXACIN COMPARED WITH LEVOFLOXACIN, OFLOXACIN, CIPROFLOXACIN, AZITHROMYCIN AND CLARITHROMYCIN AGAINST UNUSUAL AEROBIC AND ANAEROBIC HUMAN AND ANIMAL BITE-WOUND PATHOGENS

The activity of trovafloxacin and five other oral agents against 250 a erobic and 137 anaerobic strains isolated from human and animal bite w ounds was determined by an agar dilution method. Trovafloxacin was act ive against all aerobic and fastidious facultative isolates at less th an or equal to 0.5 mg/L and all anaerobes at less than or equal to 2 m g/L (Bacteroides tectum, Porphyromonas salivosa and Prevotella heparin olytica, less than or equal to 0.25 mg/L; Porphyromonas spp., less tha n or equal to 0.5 mg/L; Prevotella spp. and peptostreptococci, less th an or equal to 2.0 mg/L), except Fusobacterium nucleatum and other fus obacteria (MIC90 less than or equal to 4 mg/L). Levofloxacin was gener ally one to two dilutions more active than ofloxacin, while ciprofloxa cin was active against aerobes (MIC less than or equal to 1 mg/L) but less active against anaerobic strains (MIC90 less than or equal to 16 mg/L).