COMPARATIVE THERAPEUTIC EFFICACY OF CLINAFLOXACIN IN A PSEUDOMONAS-AERUGINOSA MOUSE RENAL ABSCESS MODEL

A deep-seated Pseudomonas aeruginosa mouse kidney abscess model was us ed to compare the therapeutic efficacy of clinafloxacin, a fluoroquino lone in clinical trials, with that of clinically relevant standard dru gs. Following 50 mg/kg oral doses, twice daily for five consecutive da ys, clinafloxacin produced a 4 log decrease in mean bacterial count, t he greatest decrease of all drugs tested. The same dosage regimen resu lted in complete bacterial eradication in 88% of the kidneys. No other compound produced total bacterial clearance in 50% of the kidneys at the highest dose tested.