HRT PRESERVES INCREASES IN BONE-MINERAL DENSITY AND REDUCTIONS IN BODY-FAT AFTER A SUPERVISED EXERCISE PROGRAM

The aims of this study were to confirm our previous finding that hormo ne-replacement therapy (HRT) augments exercise-induced increases in bo ne mineral density (BMD) in older women and to determine whether HRT p reserves the adaptations when exercise is reduced or discontinued. The study included an Ii-mo treatment phase and a 6-mo follow-up phase. P articipants, aged 66 +/- 3 yr, were assigned to control(Con; it = 10), exercise (Ex; n = 18), HRT (n = 10), and Ex + HRT (n = 16) groups. HR T was continued during the follow-up. After the treatment phase, chang es in total body BMD were -0.5 +/- 1.7, 1.5 +/- 1.4, 1.2 +/- 0.8, and 2.7 +/- 1.2% in Con, Ex, HRT, and Ex + HRT, respectively. Ex + HRT was more effective than HRT in increasing BMD of the total body and tende d (P = 0.08) to be more effective at the lumbar spine. Ex + HRT was mo re effective than Ex in increasing BMD of the total body, lumbar spine , and trochanter. Exercise-induced gains in BMD were preserved during the follow-up only in those individuals on HRT. HRT also attenuated fa t accumulation, particularly in the abdominal region, after the exerci se program. These findings suggest that HRT is an important adjunct to exercise for the prevention not only of osteoporosis but also of dise ases related to abdominal obesity.