G(S-ALPHA) MEETS ITS TARGET - SHEDDING LIGHT ON A KEY SIGNAL-TRANSDUCTION EVENT

Authors
DUMAS JJ LAMBRIGHT DG
Citation
Jj. Dumas et Dg. Lambright, G(S-ALPHA) MEETS ITS TARGET - SHEDDING LIGHT ON A KEY SIGNAL-TRANSDUCTION EVENT, Structure, 6(4), 1998, pp. 407-411
Citations number
18
Categorie Soggetti
Biophysics,Biology,"Cell Biology
Journal title
Structure → ACNP
ISSN journal
09692126
Volume
6
Issue
4
Year of publication
1998
Pages
407 - 411
Database
ISI
SICI code
0969-2126(1998)6:4<407:GMIT-S>2.0.ZU;2-1
Abstract
The recently determined crystal structure of G(s alpha) bound to a cat alytically active form of adenylyl cyclase reveals the location of the enzyme's active site and provides the first view of heterotrimeric G protein alpha subunit activating a downstream effector, Comparison wit h the structure of a catalytically inactive form of adenylyl cyclase s uggests a plausible allosteric mechanism whereby the synergistic activ ators G(s alpha) and forskolin stimulate the activity of adenylyl cycl ase, (C) Current Biology Ltd ISSN 0969-2126.