REGULATION OF G-PROTEIN SIGNALING IN YEAST

A common property of cell signaling systems is the ability to adapt to chronic stimulation. ii genetic analysis of receptor/G protein signal ing in yeast has led to the identification of a new class of regulator s of G protein signaling (RGS proteins), as well as to new insights ab out the regulatory role of G protein modifications (myristoylation, pa lmitoylation). Similar modes of regulation are now known to exist in h umans. These discoveries fill some important gaps in our understanding of signal transduction, and provide an instructive example of how mod el organisms, like yeast, can provide new insights relevant to signal regulation in higher eukaryotes. (C) 1998 Academic Press Ltd.