SYNTHESES OF 3-OXA-OPC AND 2-FLUORO-OPC HOMOLOGS

Authors
TOSHIMA H FUJINO Y ICHIHARA A KODA Y KIKUTA Y
Citation
H. Toshima et al., SYNTHESES OF 3-OXA-OPC AND 2-FLUORO-OPC HOMOLOGS, Bioscience, biotechnology, and biochemistry, 62(4), 1998, pp. 689-694
Citations number
15
Categorie Soggetti
Biology,Agriculture,"Biothechnology & Applied Migrobiology","Food Science & Tenology
Journal title
Bioscience, biotechnology, and biochemistry → ACNP
ISSN journal
09168451
Volume
62
Issue
4
Year of publication
1998
Pages
689 - 694
Database
ISI
SICI code
0916-8451(1998)62:4<689:SO3A2H>2.0.ZU;2-Z
Abstract
3-Oxa-OPC and 2-fluoro-OPC homologues which do not undergo beta-oxidat ion were synthesized from esters of odd-numbered OPC homologues by a s hort-step procedure. The 3-oxa-OPC homologues were synthesized via eth erification of an alcohol with tert-butyl bromoacetate under phase-tra nsfer conditions. The 2-fluoro-OPC homologues were synthesized via the addition of the trichloromethyl anion to an aldehyde and subsequent f luorination.