5-FLUOROURACIL DERIVATIVES - XXIII - SYNTHESIS AND ANTITUMOR ACTIVITIES OF 1-CARBAMOYL-5-FLUOROURACILS HAVING AROMATIC RING

Authors
OZAKI S KONG XZ WATANABE Y HOSHIKO T OGASAWARA T UENO T FURUKAWA U IIGO M HOSHI A
Citation
S. Ozaki et al., 5-FLUOROURACIL DERIVATIVES - XXIII - SYNTHESIS AND ANTITUMOR ACTIVITIES OF 1-CARBAMOYL-5-FLUOROURACILS HAVING AROMATIC RING, Chinese journal of chemistry, 16(2), 1998, pp. 171-177
Citations number
12
Categorie Soggetti
Chemistry
Journal title
Chinese journal of chemistry → ACNP
ISSN journal
1001604X
Volume
16
Issue
2
Year of publication
1998
Pages
171 - 177
Database
ISI
SICI code
1001-604X(1998)16:2<171:5D-X-S>2.0.ZU;2-B
Abstract
In order to get good antitumor agents especially better than 5-fluorou racil, tegafur and 1-hexylcarbamoyl-5-fluorouracil (HCFU), fourty nine 1-carbamoyl-5-fluorouracil having aromatic ring were synthesized from 5-fluorouracil acid isocyanates or amines. Antitumor activity was tes ted in the L-1210 tumor system, and 5 compounds gave better value of t herapeutic ratio than Ei-fluorouracil, tegafur, HCFU, 1-(4-Methoxybenz ylcarbamoyl)-5-fluorouracil gave the best result.