ISOLATION AND PROPAGATION OF HUMAN-PAPILLOMAVIRUS TYPE-16 IN HUMAN XENOGRAFTS IMPLANTED IN THE SEVERE COMBINED IMMUNODEFICIENCY MOUSE

Authors
BONNEZ W DARIN C BORKHUIS C JENSEN KM REICHMAN RC ROSE RC
Citation
W. Bonnez et al., ISOLATION AND PROPAGATION OF HUMAN-PAPILLOMAVIRUS TYPE-16 IN HUMAN XENOGRAFTS IMPLANTED IN THE SEVERE COMBINED IMMUNODEFICIENCY MOUSE, Journal of virology, 72(6), 1998, pp. 5256-5261
Citations number
44
Categorie Soggetti
Virology
Journal title
Journal of virology → ACNP
ISSN journal
0022538X
Volume
72
Issue
6
Year of publication
1998
Pages
5256 - 5261
Database
ISI
SICI code
0022-538X(1998)72:6<5256:IAPOHT>2.0.ZU;2-D
Abstract
We report the isolation and propagation of human papillomavirus type 1 6, the main agent of cervical cancer, using human foreskin fragments i mplanted in severe combined immunodeficiency mice. The infection produ ced viral particles, and with each passage of the virus it caused lesi ons identical to intraepithelial neoplasia, the precursor to carcinoma .