Little information has been published regarding the relative contribut
ions and exact mechanisms involved in stone fragmentation during holmi
um laser lithotripsy, High-speed photography has been used to evaluate
other intracorporeal lithotripsy devices, and we chose this method to
evaluate the holmium laser. High-speed photographic evaluation of cav
itation bubbles produced by the four fiber sizes (200, 365, 550, and 1
000 mu m) showed a moderate degree of correlation (n = 0.71 for 1 J pu
lses, r = 0.80 for 4 J pulses) between maximal bubble size and fiber d
iameter. Eliminating the data from the eroded 550 mu m fiber strengthe
ned the correlation to r = 0.94 for 1 J pulses and r = 0.99 for 4 J pu
lses. The importance of keeping fiber tips in good working condition w
as thereby demonstrated. Evidence of a thermal effect of the laser on
stone and chalk was also obtained. In a parallel study, no correlation
(r = -0.08) was found between fiber diameter and stone fragmentation
efficiency using chalk as an in vitro stone model.