ANALGESIC PROFILE OF HYDROALCOHOLIC EXTRACT OBTAINED FROM MARRUBIUM VULGARE

Marrubium vulgare L. is a medicinal plant used in folk medicine to cur e a variety of diseases. Recently we have demonstrated that a hydroalc oholic extract of this plant showed significant, nonspecific antispasm odic effects on isolated smooth muscle. In this report, we have invest igated the possible analgesic effects of the same hydroalcoholic extra ct in different models of pain in mice. The results suggest that this extract exhibits significant analgesic activity, antagonizing chemical ly-induced acute pain. Such effects may be related to the presence of steroids and terpenes, which were detected by TLC analysis.