ANTI-HIV ACTIVITY OF FLAVONOIDS AND PROANTHOCYANIDINS FROM CRATAEGUS-SINAICA

In addition to quercetin, hyperoside, rutin, vitexin, 2 ''-O-rhamnosyl vitexin, (4'''-O-acetyl)-2''-O-rhamnosylvitexin, epicatechin, procyani din B-5, proanthocyanidin A-2, procyanidin B-2 and procyanidin C-1, wh ich were reported before in Crataegus sinaica (Rosaceae), three more f lavonoids were isolated from the same plant, i.e. (+)-taxifolin, 3-O-b eta-arabinopyranosyl-(+)-taxifolin and 3-O-beta-xylopyranosyl-(+)-taxi folin. The in vitro anti-HIV activity of some selected flavonoids and proanthocyanidins was evaluated. The dimeric procyanidin B2 and proant hocyanidin A2, and especially the trimeric procyanidin C1 showed some in vitro anti-HIV activity.