LACK OF REACTIVATION OF CYTOMEGALOVIRUS (CMV) RETINITIS AFTER STOPPING CMV MAINTENANCE THERAPY IN AIDS PATIENTS WITH SUSTAINED ELEVATIONS IN CD4 T-CELLS IN RESPONSE TO HIGHLY-ACTIVE ANTIRETROVIRAL THERAPY
Jc. Macdonald et al., LACK OF REACTIVATION OF CYTOMEGALOVIRUS (CMV) RETINITIS AFTER STOPPING CMV MAINTENANCE THERAPY IN AIDS PATIENTS WITH SUSTAINED ELEVATIONS IN CD4 T-CELLS IN RESPONSE TO HIGHLY-ACTIVE ANTIRETROVIRAL THERAPY, The Journal of infectious diseases, 177(5), 1998, pp. 1182-1187
The suppression of human immunodeficiency virus (HIV) replication and
elevation in CD4 cells observed with protease inhibitor combination re
gimens known as HAART (highly active antiretroviral therapy) may allow
AIDS patients to undergo an immune recovery that allows them to suppr
ess the progression of cytomegalovirus (CMV) retinitis. Eleven AIDS pa
tients receiving HAART with healed CMV retinitis in whom CMV-specific
maintenance therapy was discontinued were studied. Median CD4 cell cou
nts were 42 before the initiation of HAART and 183 at discontinuation
of anti-CMV therapy. While a median 1.1 log(10) drop in plasma HIV-1 R
NA was obtained between starting HAART and withdrawal of maintenance t
herapy for CMV, only 3 of 11 patients maintained plasma HIV RNA below
the limits of detection. Reactivation of CMV retinitis after withdrawa
l of anti-CMV therapy did not occur in any of the patients observed fo
r a median of 156 days (range, 92-558).