AROUSAL RESPONSES TO INSPIRATORY RESISTIVE LOADING DURING REM AND NON-REM SLEEP IN NORMAL MEN AFTER SHORT-TERM SLEEP FRAGMENTATION DEPRIVATION/

Citation
M. Gugger et al., AROUSAL RESPONSES TO INSPIRATORY RESISTIVE LOADING DURING REM AND NON-REM SLEEP IN NORMAL MEN AFTER SHORT-TERM SLEEP FRAGMENTATION DEPRIVATION/, Schweizerische medizinische Wochenschrift, 128(18), 1998, pp. 698-702
Citations number
26
Categorie Soggetti
Medicine, General & Internal
ISSN journal
00367672
Volume
128
Issue
18
Year of publication
1998
Pages
698 - 702
Database
ISI
SICI code
0036-7672(1998)128:18<698:ARTIRL>2.0.ZU;2-U
Abstract
The arousal response to inspiratory resistive loading in normal men is known to be high during REM sleep compared to non-REM sleep. We inves tigated whether we could observe the same pattern, i.e. brisk arousal from REM sleep compared to non-REM sleep, in normal subjects who had u ndergone shortterm sleep fragmentation/deprivation prior to the invest igation. The arousal response to the repeated application of an extern al inspiratory resistance of 25 cm H2O/l/s was determined during REM a nd non-REM sleep in 10 healthy men after a single night with 4 hours o f acoustically fragmented sleep. The percentage of arousals to non-aro usals occurring within 2 minutes of the load application was significa ntly higher during REM sleep than during either of the non-REM sleep s tages 2 and 3/4 and decreased significantly from stage REM to stage 2 and from stage 2 to stage 3/4. The mean time to arousal in REM was sig nificantly shorter than in non-REM stage 3/4. The duration of sleep (c omparing the results of the first with the second half of the sleep pe riod time) did not modify the arousal response in stages 2 and 3/4. De spite short-term sleep fragmentation/deprivation the night before the study, the arousal response to external inspiratory resistive loading was brisker during REM than non-REM sleep in the healthy subjects stud ied. The responses were of the same magnitude as those induced in prio r studies without pretest sleep disturbance. This is different from wh at is seen in patients with sleep apnea, where breathing disorders are worst during REM sleep and sleep fragmentation/deprivation leads to r apid deterioration of arousal responses to the spontaneously occurring airway occlusions.