SURVIVAL PROGNOSIS OF OVARIAN-CARCINOMA F IGO STAGES-III-IV - 1980-1985 VERSUS 1986-1993

We examined the survival prognosis of 638 patients who had ovarian car cinoma Figo stages III and IV. We considered two separate time periods , 1980-1985 versus 1986-1993, including the size of the postoperative residual tumor, polychemotherapy with and without platinum, histologic al grading 1 versus 2 and 3, Figo stage III versus IV, and ascites pre sent versus no ascites. Since 1986, 96% of the patients received plati num-containing polychemotherapy at a dosage of greater than or equal t o 75 mg/m(2), whereas between 1980 and 1985, only 76% of these patient s received platinum-containing polychemotherapy at a dosage of 50 mg/m (2), and 24% of the patients received polychemotherapy without platinu m. The size of residual tumor masses and also the time period of treat ment had an independent influence on survival prognosis. Patients trea ted from 1980 to 1985 had a relative risk to die which was 1,44 times higher than for the patients who were studied from 1986 to 1993.