A SYNTHETIC STRATEGY TO A NEW CLASS OF CYCLOALKANE RING-FUSED PYRIDINE NUCLEOSIDES AS POTENTIAL ANTI-HIV AGENTS

Condensation of cyanothioacetamide or cyanoacetamide with sodium salts of 2-formyl-1-cycloalkanones afforded the corresponding cycloalkane r ing fused pyridine-2(1H)-thiones and -2-pyridones. The latter compound s served as a key intermediates for the synthesis of a new class of cy cloalkane ring fused pyridine glycosides.