This study attempts to identify the specific role that each of three c
onditions afflicting homeless, mentally ill, chemically misusing (HMIC
M) men plays in exposing these men to the risk of HN infection. Three
hundred and fifteen HMICM men (33 of whom were HlV+) were interviewed
on intravenous drug use (IVDU) and sex practices. Two scales of risky
IVDU practices and sex conducts were constructed and analyzed in relat
ion to HIV status. The severity of homelessness, mental illness, and c
hemical misuse, then, were analyzed as possible predictors of risky IV
DU and sex practices. Strong correlations were found between IVDU prac
tices and HIV seropositivity, and between risky sex conduct and HIV se
ropositivity. Serious depression was the strongest predictor of risky
IVDU practices. Prolonged homelessness was the condition most associat
ed with risky sexual conduct. This study concludes that HMICM men are
at high risk for HN infection, stemming, predominately, from two condi
tions: depression, leading to risky IVDU practices, and homelessness,
leading to risky sex conduct with two separate types of risky behavior
.