The human immunodeficiency virus (HIV) pandemic has swept through inje
cting drug user (IDU) communities around the world, Once HIV is presen
t in an IDU community, seroprevalence rates escalate rapidly unless im
mediate and comprehensive prevention methods are put in place. Such me
asures often include providing IDUs with sterile injecting equipment a
nd dispensing methadone or other opiate substitution formulas. These m
easures fall under the rubric of harm reduction-an attempt to reduce t
he harm to drug users, their families, and communities, including prev
enting or limiting the transmission of HIV and other blood-borne virus
es. In Thailand, HIV-1 spread rapidly among IDUs with seroprevalence r
ates jumping from 1 to 40% in the space of a year. Current incidence r
ates are estimated at 11 per 100 person years. This paper describes th
e establishment and implementation of needle and syringe exchanges amo
ng injecting drug users in nine Hilltribe communities in Northern Thai
land. The exchanges have been operating for between 1 and 3 years and
have been effective in limiting the transmission of HIV within these s
mall communities. The needle and syringe exchanges are run by indigeno
us staff with the cooperation of the community and provide a good exam
ple of the feasibility of establishing locally-run, community-based ha
rm reduction programs.