PROBE BEAM DEFLECTION STUDY ON ELECTROCHEMICALLY CONTROLLED-RELEASE OF 5-FLUOROURACIL

Citation
H. Huang et al., PROBE BEAM DEFLECTION STUDY ON ELECTROCHEMICALLY CONTROLLED-RELEASE OF 5-FLUOROURACIL, Electrochimica acta, 43(9), 1998, pp. 999-1004
Citations number
30
Categorie Soggetti
Electrochemistry
Journal title
ISSN journal
00134686
Volume
43
Issue
9
Year of publication
1998
Pages
999 - 1004
Database
ISI
SICI code
0013-4686(1998)43:9<999:PBDSOE>2.0.ZU;2-Q
Abstract
In this paper, the polypyrrole (PPy) film modified electrodes are used as an electroreleasing reservoir. The electrochemically controlled re lease of 5-fluorouracil (5-FU) from a PPy film modified electrode to a queous electrolytes is studied by the in situ probe beam deflection (P BD) method combined with cyclic voltammetry (CV) and chronoamperometry (CA). The PBD results reveal that the release of 5-FU from PPy film d epends on the electrochemical redox process of the PPy film electrode. The released amount is controlled by the reduction potential and is p roportional to the thickness of the film. The exchange of 5-FU anions with Cl- on an open circuit is slow on the time scale of minutes, but the release of 5-FU anions can proceed quickly at -0.6 V (vs Ag/AgCl). The amount of released 5-FU decreases with the time that the PPy film is soaked in aqueous solution. (C) 1998 Elsevier Science Ltd. All rig hts reserved.