CONCOMITANT ENDOMETRIAL HYPERPLASIA IN PATIENTS WITH ENDOMETRIAL CARCINOMA

Objectives. The aim of this study was to compare the histopathologic f eatures and prognosis of patients with endometrial carcinoma with and without concomitant hyperplasia. Methods. Histologic slides of the sur gical specimens of 214 consecutive patients who underwent surgery as p rimary treatment for endometrial carcinoma from 1985 through 1991 were reviewed. Results. Ninety-two of the 214 patients (43%) with endometr ial carcinoma had concomitant endometrial hyperplasia. Patients with e ndometrial carcinoma with hyperplasia were significantly younger than those without hyperplasia (mean age 62 +/- 10 vs 65 +/- 9 years, P < 0 .05). Carcinomas associated with hyperplasia were better differentiate d and of lower surgical stage. By univariate analysis the frequency of recurrence was significantly lower (4% vs 17%, P < 0.004) and the est imated 5-year survival rate significantly higher (96% vs 85%, P < 0.01 ) in patients with endometrial carcinoma with concomitant hyperplasia. However, in multivariate analysis the presence of endometrial hyperpl asia was not an independent prognostic factor and the 5-year survival rates of patients with or without hyperplasia did not differ significa ntly in any surgical stage. Conclusion. The presence or absence of con comitant endometrial hyperplasia is strongly correlated with the surgi cal stage of endometrial carcinoma. (C) 1998 Academic Press.