COI1 - AN ARABIDOPSIS GENE REQUIRED FOR JASMONATE-REGULATED DEFENSE AND FERTILITY

The coi1 mutation defines an Arabidopsis gene required for response to jasmonates, which regulate defense against insects and pathogens, wou nd healing, and pollen fertility. The wild-type allele, COI1, was mapp ed to a 90-kilobase genomic fragment and located by complementation of coi1-1 mutants. The predicted amino acid sequence of the COI1 protein contains 16 leucine-rich repeats and an F-box motif. It has similarit y to the F-box proteins Arabidopsis TIR1, human Skp2, and yeast Grr1, which appear to function by targeting repressor proteins for removal b y ubiquitination.