REGULATION OF TRANSLATION INITIATION-FACTORS BY SIGNAL-TRANSDUCTION

Authors
KLEIJN M SCHEPER GC VOORMA HO THOMAS AAM
Citation
M. Kleijn et al., REGULATION OF TRANSLATION INITIATION-FACTORS BY SIGNAL-TRANSDUCTION, European journal of biochemistry, 253(3), 1998, pp. 531-544
Citations number
175
Categorie Soggetti
Biology
Journal title
European journal of biochemistry → ACNP
ISSN journal
00142956
Volume
253
Issue
3
Year of publication
1998
Pages
531 - 544
Database
ISI
SICI code
0014-2956(1998)253:3<531:ROTIBS>2.0.ZU;2-G
Abstract
Regulation of eukaryotic translation initiation is a process that requ ires collaboration between multiple proteins. The cap-binding factor e ukaryotic initiation factor (eIF)4E, its binding protein 4E-BP1, and t he guanine-nucleotide-exchange factor eIF2B play important roles in th e regulation of the rate of protein synthesis. This review describes t he regulation of the activity of these three proteins and the signal-t ransduction pathways involved therein.