GENETIC CHANGES AND TELOMERASE ACTIVITY IN HUMAN RENAL-CELL CARCINOMA

Citation
V. Rohde et al., GENETIC CHANGES AND TELOMERASE ACTIVITY IN HUMAN RENAL-CELL CARCINOMA, Clinical cancer research, 4(1), 1998, pp. 197-202
Citations number
26
Categorie Soggetti
Oncology
Journal title
ISSN journal
10780432
Volume
4
Issue
1
Year of publication
1998
Pages
197 - 202
Database
ISI
SICI code
1078-0432(1998)4:1<197:GCATAI>2.0.ZU;2-A
Abstract
Using the sensitive telomeric repeat amplification protocol assay, we detected telomerase activity in 26 of 35 (74.3%) renal cell carcinomas analyzed. Subdivision of the tumors according to telomerase activity did not reveal an obvious association between the presence of telomera se activity and histomorphological stage, grade, tumor size, or DNA pl oidy. Furthermore, no association was found between telomerase activit y and a distinct chromosomal aberration pattern; namely, loss of genet ic material on the short arm of chromosome 3. Telomerase activity was also detected in 6 of 35 (17.1%) normal corresponding renal tissue sam ples, which seems interesting in light of the supposed biological role of telomerase expression in carcinogenesis. Interestingly, telomerase activity was detected in three of the four (75%) kidneys bearing non- clear cell tumor types, whereas of the 31 kidneys with clear cell carc inomas, telomerase activity was found in only 3 (9.7%) normal tissue s amples. In addition, the two renal angiomyolipomas and one of the two analyzed transitional cell carcinomas of the renal pelvis were telomer ase negative.