EFFECT OF CCK ON PROXIMAL GASTRIC MOTOR FUNCTION IN HUMANS

We have studied the effect of CCK on proximal gastric motor function i n humans. Seven healthy volunteers participated in three experiments p erformed in random order during continuous intravenous infusion of 1) saline (control), 2) 0.5 IDU.kg(-1).h(-1) CCK, and 3) 1.0 IDU.kg(-1).h (-1) CCK. Proximal gastric mechanics were measured by an electronic ba rostat, and abdominal symptoms were scored by visual analog scales. In fusion of 0.5 and 1.0 IDU.kg(-1).h(-1) CCK resulted in plasma CCK leve ls (RIA) in the postprandial range. CCK induced gastric relaxation; at 2 mmHg above intra-abdominal pressure the intragastric volume during 1.0 IDU.kg(-1).h(-1) CCK was significantly increased over saline (363 +/- 44 vs. 195 +/- 34 ml; P < 0.01) but not during 0.5 IDU.kg(-1).h(-1 ) CCK (195 +/- 14 ml; not significant). During both isovolumetric and isobaric distensions, 1.0 IDU.kg(-1).h(-1) CCK significantly (P < 0.05 ) increased proximal gastric compliance compared with saline. However, 0.5 IDU.kg(-1).h(-1) CCK had, no significant effect on gastric compli ance. During volume distensions, but not during fixed pressure distens ions, 1.0 IDU.kg(-1).h(-1) CCK significantly (P < 0.05) reduced viscer al perception. These results suggest that in humans CCK may have a phy siological role in regulating proximal gastric mechanics.