ANTITUBERCULOSIS MACROMOLECULAR PRODRUGS - PART 1 - ISONIAZID CONJUGATES WITH POLY(ETHYLENE GLYCOL) DERIVATIVES

Authors
CRUZ ML GIL MH
Citation
Ml. Cruz et Mh. Gil, ANTITUBERCULOSIS MACROMOLECULAR PRODRUGS - PART 1 - ISONIAZID CONJUGATES WITH POLY(ETHYLENE GLYCOL) DERIVATIVES, Journal of bioactive and compatible polymers, 13(2), 1998, pp. 146-157
Citations number
24
Categorie Soggetti
Polymer Sciences","Biothechnology & Applied Migrobiology","Materials Science, Biomaterials
Journal title
Journal of bioactive and compatible polymers → ACNP
ISSN journal
08839115
Volume
13
Issue
2
Year of publication
1998
Pages
146 - 157
Database
ISI
SICI code
0883-9115(1998)13:2<146:AMP-P1>2.0.ZU;2-X
Abstract
The synthesis, elemental and spectrometric analysis of isoniazid conju gates with poly(ethylene glycol) (PEG) were obtained. In the first par t of the work, acyl isoniazid, hydroxymethyl isoniazid, and modified p oly(ethylene glycol) were synthesized. These compounds were characteri zed by FTIR, by elemental analysis, and by NMR. To obtain antitubercul osis macromolecular prodrugs with sustained delivery, the modified PEG were used as carriers by linking, via end group, either isoniazid or its hydroxymethyl derivative.