POPULATION STUDY ON THE INHERITANCE OF LAC-Z GENE IN TRANSGENIC MICE

Two populations were created, one experimental, descended from transge nic (bacterial Lac-Z gene) founder males and the second control, desce nded from nontransgenic males. The transgenic and nontransgenic males were mated to females obtained from a population mated ar random over many generations. In each population and each generation, body weight at the age of 21 and 42 days, weight gains, fertility and prolificacy- litter size ac birth, at the age oi 21 and 42 days were examined. In t he experimental pop on the frequency of transgenic animals nias calcul ated. In the seventh generation the frequency of transgenic animals wa s 30 %. The results presented here indicate that for most of the trait s examined, descendants oi transgenic males proved to be of poorer qua lity than those with nontransgenic sires. The results suggest that the transgenic genotype of the dam has a negative effect on the growth tr aits. The fertility of both transgenic and nontransgenic animals was h igh and amounted to nearly 100 %.