REFINED GENETIC-MAPPING OF AUTOSOMAL-DOMINANT RETINITIS-PIGMENTOSA LOCUS RP18 REDUCES THE CRITICAL REGION TO 2 CM BETWEEN D1S442 AND D1S2858 ON CHROMOSOME-1Q

Linkage analysis was performed on a large Danish family to refine the position of RP18, the locus for autosomal dominant retinitis pigmentos a, mapped previously between D1S534 and D1S305 in chromosome 1p13-q21. We genotyped the family members for five microsatellite-type DNA poly morphisms and mapped RP18 between D1S422 and D1S2858 to a region of le ss than 2 cM. No obvious candidate gene has yet been assigned to the c hromosomal interval defined here.