CHONDROMYXOID FIBROMA OF BONE - A CLINICOPATHOLOGICAL REVIEW OF 278 CASES

In a study of the clinical, radiographic, and pathological features of chondromyxoid fibroma, the tumor was slightly more common in men, usu ally in the second decade of Life. Almost half of the tumors Involved the long bones, although the ilium and the small bones were also commo n sites. Roentgenograms showed a sharply marginated, lobulated, lucent defect in the metaphysis. The tumor involved the medullary bone in an eccentric fashion, and the cortex was thinned and expanded. Periostea l reaction and soft tissue extension were uncommon. Mineralization was identified in 13% of the lesions. Histologically, the tumors were alm ost always arranged in lobules, which were prominent (macrolobular) or somewhat indistinct (microlobular). The tumor cells were spindle-shap ed or stellate and arranged in a myxoid matrix. Calcification was seen in more than one third of the cases but was rarely prominent. Hyaline cartilage and chondroblastoma-like areas were not uncommon. Approxima tely 18% of tumors showed bizarre nuclei. Permeation of bony trabecula e was uncommon. Treatment was conservative surgical removal; approxima tely one fourth of the patients had recurrence. Copyright (C) 1998 by W.B. Saunders Company.