ENHANCEMENT OF THE EFFECT OF METHOTREXATE ON COLLAGEN II INDUCED ARTHRITIS IN MICE BY NICOTINAMIDE

Authors
KROGER H HAUSCHILD A OHDE M THEFELD W KRUGER D BACHE K EHRLICH W
Citation
H. Kroger et al., ENHANCEMENT OF THE EFFECT OF METHOTREXATE ON COLLAGEN II INDUCED ARTHRITIS IN MICE BY NICOTINAMIDE, Inflammation, 22(3), 1998, pp. 277-285
Citations number
20
Categorie Soggetti
Cell Biology",Immunology,Biology
Journal title
Inflammation → ACNP
ISSN journal
03603997
Volume
22
Issue
3
Year of publication
1998
Pages
277 - 285
Database
ISI
SICI code
0360-3997(1998)22:3<277:EOTEOM>2.0.ZU;2-J
Abstract
Treatment with a combination of 10 mg/kg i.p. methotrexate and 100 mg/ kg i.p. nicotinamide inhibits the development of collagen II induced a rthritis in male DBA/1 X B.10(4R) mice, as assessed by the arthritic i ndex and whole blood chemiluminescence. The effect is much more pronou nced than with either methotrexate or nicotinamide alone at the same c oncentrations. Determination of GOT and GPT levels in the blood reveal ed that the treatment causes no toxic side effects on the liver.