This paper reviews the available data on low- and high-energy transure
thral microwave thermotherapy (TUMT) in the treatment of patients with
benign prostatic hyperplasia (BPH). Furthermore, it provides a perspe
ctive for this minimally invasive treatment modality in the selection
of patients and in future developments. In evaluations of the two soft
ware modalities, several clinical studies have proved them to be effec
tive. Whereas the lower-energy software seems to be the better choice
for treatment of patients with lower urinary tract symptoms who have a
lower grade of outlet obstruction and a smaller prostate, the higher-
energy mode should be used to deobstruct and can be used in patients w
ith larger prostates and moderate to severe outlet obstruction. Althou
gh baseline parameters can be used to predict the response to treatmen
t in the higher-energy software mode, the total amount of energy remai
ns very important for the final outcome, and future efforts should be
encouraged to quantify prostate vascularization and histology in relat
ion to transurethral microwave heating. Furthermore, future developmen
ts should focus on shorter treatment times and minimization of morbidi
ty.