THE DESIGN AND SYNTHESIS OF INHIBITORS OF THE CYSTEINYL PROTEASE, DERP I

Authors
BILLSON J CLARK J CONWAY SP HART T JOHNSON T LANGSTON SP RAMJEE M QUIBELL M SCOTT RK
Citation
J. Billson et al., THE DESIGN AND SYNTHESIS OF INHIBITORS OF THE CYSTEINYL PROTEASE, DERP I, Bioorganic & medicinal chemistry letters, 8(9), 1998, pp. 993-998
Citations number
34
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
9
Year of publication
1998
Pages
993 - 998
Database
ISI
SICI code
0960-894X(1998)8:9<993:TDASOI>2.0.ZU;2-3
Abstract
Prototype irreversible inhibitors of the cysteinyl protease Der p I we re designed, synthesised and evaluated in vitro. Candidates were desig ned using a modular approach, whereby a peptide sequence was appended with known thiophilic moieties. This hinged on utilizing peptide seque nces from substrate specificity data compiled using proprietary RAPiD( (TM)) technology. (C) 1998 Elsevier Science Ltd. All rights reserved.