SYNTHESIS OF DNA ANALOGS WITH NOVEL CARBOXAMIDOMETHYL PHOSPHONAMIDE AND GLYCINAMIDE INTERNUCLEOSIDE LINKAGES

Authors
EFIMOV VA BURYAKOVA AA CHAKHMAKHCHEVA OG
Citation
Va. Efimov et al., SYNTHESIS OF DNA ANALOGS WITH NOVEL CARBOXAMIDOMETHYL PHOSPHONAMIDE AND GLYCINAMIDE INTERNUCLEOSIDE LINKAGES, Bioorganic & medicinal chemistry letters, 8(9), 1998, pp. 1013-1018
Citations number
21
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
9
Year of publication
1998
Pages
1013 - 1018
Database
ISI
SICI code
0960-894X(1998)8:9<1013:SODAWN>2.0.ZU;2-T
Abstract
Thymidine oligonucleotide analogues with phosphodiester bonds fully su bstituted by carboxamidomethyl phosphonamide, or glycinamide linkages were synthesized on a solid support, and their hybridization propertie s toward DNA and RNA targets were determined by Tm analysis. (C) 1998 Elsevier Science Ltd. All rights reserved.