MECHANISM OF 17-ALPHA-HYDROXYLASE 17,20-LYASE - AN INITIAL GEOMETRIC PERSPECTIVE FOR THE LYASE OF THE C(17)-C(20) BOND OF C-21 STEROIDS/

Authors
AHMED S OWEN CP
Citation
S. Ahmed et Cp. Owen, MECHANISM OF 17-ALPHA-HYDROXYLASE 17,20-LYASE - AN INITIAL GEOMETRIC PERSPECTIVE FOR THE LYASE OF THE C(17)-C(20) BOND OF C-21 STEROIDS/, Bioorganic & medicinal chemistry letters, 8(9), 1998, pp. 1023-1028
Citations number
8
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
9
Year of publication
1998
Pages
1023 - 1028
Database
ISI
SICI code
0960-894X(1998)8:9<1023:MO11-A>2.0.ZU;2-W
Abstract
Using the novel 'substrate-heme complex' approach(1), the mechanism of 17 alpha-Hydroxylase/1 7,20-Lyase (P-450(17 alpha)), in particular th e lyase of the C(17)-C(20) bond, is considered from a geometric perspe ctive. The results of the study appear to suggest that the final oxida tive step in the lyase of the C(17)-C(20) bond involves the use of a f erroxy attacking species as opposed to peroxy or a mixture of ferroxy and peroxy, an observation which is consistent with results previously Obtained with Aromatase(1). (C) 1998 Elsevier Science Ltd. All rights reserved.