POTENT ANTIMITOTIC AND CELL-GROWTH INHIBITORY PROPERTIES OF SUBSTITUTED CHALCONES

Authors
DUCKI S FORREST R HADFIELD JA KENDALL A LAWRENCE NJ MCGOWN AT RENNISON D
Citation
S. Ducki et al., POTENT ANTIMITOTIC AND CELL-GROWTH INHIBITORY PROPERTIES OF SUBSTITUTED CHALCONES, Bioorganic & medicinal chemistry letters, 8(9), 1998, pp. 1051-1056
Citations number
27
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
9
Year of publication
1998
Pages
1051 - 1056
Database
ISI
SICI code
0960-894X(1998)8:9<1051:PAACIP>2.0.ZU;2-W
Abstract
A series of substituted chalcones was synthesised and screened for cyt otoxic activity against the K562 human leukaemia cell line. thyl-1-(3' ,4',5'-trimethoxyphenyl)-prop-2-en-1-one [IC50 (K562) 0.21 nM] was fou nd to be the most active. A relationship between the conformation and cytotoxicity of the chalcones is discussed. (C) 1998 Elsevier Science Ltd. All rights reserved.