POLYMER-SUPPORTED BASES IN SOLUTION-PHASE SYNTHESIS - 2 - A CONVENIENT METHOD FOR N-ALKYLATION REACTIONS OF WEAKLY ACIDIC HETEROCYCLES

Authors
XU W MOHAN R MORRISSEY MM
Citation
W. Xu et al., POLYMER-SUPPORTED BASES IN SOLUTION-PHASE SYNTHESIS - 2 - A CONVENIENT METHOD FOR N-ALKYLATION REACTIONS OF WEAKLY ACIDIC HETEROCYCLES, Bioorganic & medicinal chemistry letters, 8(9), 1998, pp. 1089-1092
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
9
Year of publication
1998
Pages
1089 - 1092
Database
ISI
SICI code
0960-894X(1998)8:9<1089:PBISS->2.0.ZU;2-O
Abstract
A convenient solution-phase method for N-alkylation reactions of weakl y acidic heterocycles employing polymer supported super base PBEMP is described. By using this method, multiple-step and chemoselective N-al kylation sequences can be carried out in a one-pot process. (C) 1998 E lsevier Science Ltd. All rights reserved.