ANTI-INFLAMMATORY ANTIARTHRITIC KETONIC BISPHOSPHONIC ACID-ESTERS/

Authors
SCHLACHTER ST GALINET LA SHIELDS SK ASPAR DG DUNN CJ STAITE ND NUGENT RA
Citation
St. Schlachter et al., ANTI-INFLAMMATORY ANTIARTHRITIC KETONIC BISPHOSPHONIC ACID-ESTERS/, Bioorganic & medicinal chemistry letters, 8(9), 1998, pp. 1093-1096
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
9
Year of publication
1998
Pages
1093 - 1096
Database
ISI
SICI code
0960-894X(1998)8:9<1093:AAKBA>2.0.ZU;2-9
Abstract
Bisphosphonate ester 2 is an inhibitor of inflammation, but is devoid of antiarthritic effects. SAR studies on a series of related bisphosph onate esters resulted in compounds 6e, 6i, 6j, and 6m, which exhibited excellent inhibition of an arthritis model, in addition to potent ant i-inflammatory effects. (C) 1998 Elsevier Science Ltd. All rights rese rved.