SYNTHESIS OF BETA-DIFLUORINE-CONTAINING AMINO-ACIDS

Citation
Kq. Li et al., SYNTHESIS OF BETA-DIFLUORINE-CONTAINING AMINO-ACIDS, Bioorganic & medicinal chemistry letters, 8(9), 1998, pp. 1097-1100
Citations number
28
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
ISSN journal
0960894X
Volume
8
Issue
9
Year of publication
1998
Pages
1097 - 1100
Database
ISI
SICI code
0960-894X(1998)8:9<1097:SOBA>2.0.ZU;2-U
Abstract
A convenient strategy was developed to prepare several B-difluoroamino acids. As exemplified by the synthesis of 3,3-difluoro-L-homocysteine , 3,3-difluoro-L-homoserine and 3,3-difluoro-L-methionine, the reactio n sequence all started from L-isoascorbic acid. This approach holds po tential to be extended to make other beta-difluorine-containing amino acids. (C) 1998 Elsevier Science Ltd. All rights reserved.