SEROTONERGIC ERGOLINE DERIVATIVES

Authors
MANTEGANI S BRAMBILLA E CACCIA C DAMIANI G FORNARETTO MG MCARTHUR RA VARASI M
Citation
S. Mantegani et al., SEROTONERGIC ERGOLINE DERIVATIVES, Bioorganic & medicinal chemistry letters, 8(9), 1998, pp. 1117-1122
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
9
Year of publication
1998
Pages
1117 - 1122
Database
ISI
SICI code
0960-894X(1998)8:9<1117:SED>2.0.ZU;2-6
Abstract
Novel classes of 13- and 14-tertbutyl-ergoline derivatives were prepar ed, and characterised in vitro for their affinity for adrenergic, dopa minergic and serotonergic binding sites. This study particularly exami nes the importance of the presence and the position of the tert-butyl group in conferring either significant 5-HT1A or 5-HT2 affinity and se lectivity respectively. (C) 1998 Elsevier Science Ltd. All rights rese rved.